Genome-wide copy number variation analysis in extended families and unrelated individuals characterized for musical aptitude and creativity in music.

ABSTRACT: Music perception and practice represent complex cognitive functions of the human brain. Recently, evidence for the molecular genetic background of music related phenotypes has been obtained. In order to further elucidate the molecular background of musical phenotypes we analyzed genome wide copy number variations (CNVs) in five extended pedigrees and in 172 unrelated subjects characterized for musical aptitude and creative functions in music. Musical aptitude was defined by combination of the scores of three music tests (COMB scores): auditory structuring ability, Seashores test for pitch and for time. Data on creativity in music (herein composing, improvising and/or arranging music) was surveyed using a web-based questionnaire.Several CNVRs containing genes that affect neurodevelopment, l

SUBMITTER: Ukkola-Vuoti L 

PROVIDER: S-EPMC3584088 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature