Biferrocene-Based Diphosphine Ligands: Synthesis and Application of Walphos Analogues in Asymmetric Hydrogenations.

ABSTRACT: A total of four biferrocene-based Walphos-type ligands have been synthesized, structurally characterized, and tested in the rhodium-, ruthenium- and iridium-catalyzed hydrogenation of alkenes and ketones. Negishi coupling conditions allowed the biferrocene backbone of these diphosphine ligands to be built up diastereoselectively from the two nonidentical and nonracemic ferrocene fragments (R)-1-(N,N-dimethylamino)ethylferrocene and (S_Fc)-2-bromoiodoferrocene. The molecular structures of (S_Fc)-2-bromoiodoferrocene, the coupling product, two ligands, and the two complexes ([PdCl₂(L)] and [RuCl(p-cymene)(L)]PF₆) were determined by X-ray diffraction. The structural features of complexes and the catalysis resu

SUBMITTER: Zirakzadeh A 

PROVIDER: S-EPMC3584622 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature