Identification of a genetic locus on chromosome 4q34-35 for type 2 diabetes with overweight.

ABSTRACT: The incidence of type 2 diabetes is rising rapidly because of an increase in the incidence of being overweight and obesity. Identification of genetic determinants for complex diseases, such as type 2 diabetes, may provide insight into disease pathogenesis. The aim of the study was to investigate the shared genetic factors that predispose individuals to being overweight and developing type 2 diabetes. We conducted genome-wide linkage analyses for type 2 diabetes in 386 affected individuals (269 sibpairs) from 171 Korean families and association analyses with single-nucleotide polymorphisms of candidate genes within linkage regions to identify genetic variants that predispose individuals to being overweight and developing type 2 diabetes. Through fine-mapping analysis of chromosome 4q34-35,

SUBMITTER: Park MH 

PROVIDER: S-EPMC3584667 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature