Somatic mutations of STK11 gene in human papillomavirus positive and negative penile cancer.

ABSTRACT:

Background

Human papillomavirus (HPV) infection accounts for about 40-50% of all cases of penile carcinoma suggesting that other factors, including host genetic status, are involved in neoplastic transformation. In this perspective, STK11 gene, which has been found frequently mutated in HPV-related cervical carcinoma, has been analyzed in HPV-positive and HPV-negative invasive penile cancers to establish its mutational status and the possible correlation of HPV infection with specific genetic alterations.

Methods

Genomic DNAs extracted from 26 cases of penile squamous cell carcinoma were analyzed for genetic alterations in the exons 1 to 9 of STK11 gene by quantitative real-time PCR. Ratios of potentially deleted and non-deleted exons were indicative of specific loss of STK1

SUBMITTER: Annunziata C 

PROVIDER: S-EPMC3584742 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature