Concomitant prediction of function and fold at the domain level with GO-based profiles.

ABSTRACT: Predicting the function of newly sequenced proteins is crucial due to the pace at which these raw sequences are being obtained. Almost all resources for predicting protein function assign functional terms to whole chains, and do not distinguish which particular domain is responsible for the allocated function. This is not a limitation of the methodologies themselves but it is due to the fact that in the databases of functional annotations these methods use for transferring functional terms to new proteins, these annotations are done on a whole-chain basis. Nevertheless, domains are the basic evolutionary and often functional units of proteins. In many cases, the domains of a protein chain have distinct molecular functions, independent from each other. For that reason resources with functio

SUBMITTER: Lopez D 

PROVIDER: S-EPMC3584904 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature