Function prediction from networks of local evolutionary similarity in protein structure.

ABSTRACT:

Background

Annotating protein function with both high accuracy and sensitivity remains a major challenge in structural genomics. One proven computational strategy has been to group a few key functional amino acids into templates and search for these templates in other protein structures, so as to transfer function when a match is found. To this end, we previously developed Evolutionary Trace Annotation (ETA) and showed that diffusing known annotations over a network of template matches on a structural genomic scale improved predictions of function. In order to further increase sensitivity, we now let each protein contribute multiple templates rather than just one, and also let the template size vary.

Results

Retrospective benchmarks in 605 Structural Genomics enzymes showed

SUBMITTER: Erdin S 

PROVIDER: S-EPMC3584919 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature