New approaches with different types of circulating cathodic antigen for the diagnosis of patients with low Schistosoma mansoni load.

ABSTRACT:

Background

Schistosomiasis mansoni is a debilitating and sometimes fatal disease. Accurate diagnosis plays a key role in patient management and infection control. However, currently available parasitological methods are laborious and lack sensitivity. The selection of target antigen candidates has turned out to be a promising tool for the development of more sensitive diagnostic methods. In our previous investigations, the use of crude antigens led to false-positive results. Recently, focus has been given to highly purified Schistosoma mansoni antigens, especially to circulating antigens.

Method

Thus, our main goal was to test different types of circulating cathodic antigen glycoprotein (CCA), as "crude antigen," the protein chain of recombinant CCA and two individual peptid

SUBMITTER: Grenfell R 

PROVIDER: S-EPMC3585039 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature