Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.

ABSTRACT: Genetic variation contributes to host responses and outcomes following infection by influenza A virus or other viral infections. Yet narrow windows of disease symptoms and confounding environmental factors have made it difficult to identify polymorphic genes that contribute to differential disease outcomes in human populations. Therefore, to control for these confounding environmental variables in a system that models the levels of genetic diversity found in outbred populations such as humans, we used incipient lines of the highly genetically diverse Collaborative Cross (CC) recombinant inbred (RI) panel (the pre-CC population) to study how genetic variation impacts influenza associated disease across a genetically diverse population. A wide range of variation in influenza disease related

SUBMITTER: Ferris MT 

PROVIDER: S-EPMC3585141 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature