Association of diabetes and tuberculosis: impact on treatment and post-treatment outcomes.

ABSTRACT:

Objective

To determine the clinical consequences of pulmonary tuberculosis (TB) among patients with diabetes mellitus (DM).

Methods

We conducted a prospective study of patients with TB in Southern Mexico. From 1995 to 2010, patients with acid-fast bacilli or Mycobacterium tuberculosis in sputum samples underwent epidemiological, clinical and microbiological evaluation. Annual follow-ups were performed to ascertain treatment outcome, recurrence, relapse and reinfection.

Results

The prevalence of DM among 1262 patients with pulmonary TB was 29.63% (n=374). Patients with DM and pulmonary TB had more severe clinical manifestations (cavities of any size on the chest x-ray, adjusted OR (aOR) 1.80, 95% CI 1.35 to 2.41), delayed sputum conversion (aOR 1.51, 95% CI 1.09 to 2.1

SUBMITTER: Jimenez-Corona ME 

PROVIDER: S-EPMC3585483 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature