Known glioma risk loci are associated with glioma with a family history of brain tumours -- a case-control gene association study.

ABSTRACT: Familial cancer can be used to leverage genetic association studies. Recent genome-wide association studies have reported independent associations between seven single nucleotide polymorphisms (SNPs) and risk of glioma. The aim of this study was to investigate whether glioma cases with a positive family history of brain tumours, defined as having at least one first- or second-degree relative with a history of brain tumour, are associated with known glioma risk loci. One thousand four hundred and thirty-one glioma cases and 2,868 cancer-free controls were identified from four case-control studies and two prospective cohorts from USA, Sweden and Denmark and genotyped for seven SNPs previously reported to be associated with glioma risk in case-control designed studies. Odds ratios were calcul

SUBMITTER: Melin B 

PROVIDER: S-EPMC3586297 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature