Effects of growth hormone withdrawal in obese premenopausal women.

ABSTRACT:

Objective

We previously reported improved body composition and cardiovascular risk markers plus a small decrease in glucose tolerance with GH administration vs placebo for 6 months to abdominally obese premenopausal women. The objective of this study was to determine whether the effects of GH treatment on cardiovascular risk markers, body composition and glucose tolerance in obese women persist 6 months after GH withdrawal.

Design and patients

Fifty abdominally obese premenopausal women completed a trial of rhGH vs placebo for 6 months; thirty-nine women completed a subsequent 6-month withdrawal observation period.

Measurements

IGF-I, body composition by CT, (1) H-MRS and DXA, serum cardiovascular risk markers, oral glucose tolerance test (OGTT).

Results

IGF-I

SUBMITTER: Lin E 

PROVIDER: S-EPMC3586770 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature