Molecular Analysis of A2-genes Encoding Stage-specific S Antigen-like Proteins among Isolates from Iranian Cutaneous and Visceral Leishmaniasis.

ABSTRACT:

Objectives

Leishmania can lead to a broad spectrum of diseases, collectively known as leishmaniasis. The A2 gene/ protein family could be one of the most eligible candidate factors of virulence in visceral leishmaniasis (VL). The previous results confirmed that in Leishmania infantum, several A2 proteins are abundantly expressed by the amastigote, but not the promastigote stage. As there are no data available on the pattern of A2 gene / protein in Iranian Leishmania isolates of either cutaneous leishmaniasis (CL) or VL; the current study aimed to investigate molecular analysis of A2 gene in leishmania species among field isolates of .

Materials and methods

An A2 gene was identified by sequencing of crude PCR products resulting from 20 samples of CL and 10 samples of VL isola

SUBMITTER: Farahmand M 

PROVIDER: S-EPMC3586840 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature