Association of histologic variants in FSGS clinical trial with presenting features and outcomes.

ABSTRACT:

Background and objectives

FSGS histologic variants have correlated with outcomes in retrospective studies. The FSGS Clinical Trial provided a unique opportunity to study the clinical impact of histologic variants in a well defined prospective cohort with steroid-resistant primary FSGS.

Design, setting, participants, & measurements

Renal biopsies of 138 FSGS Clinical Trial participants aged 2-38 years enrolled from 2004 to 2008 were analyzed using the Columbia classification by core pathologists. This study assessed the distribution of histologic variants and examined their clinical and biopsy characteristics and relationships to patient outcomes.

Results

The distribution of histologic variants was 68% (n=94) FSGS not otherwise specified, 12% (n=16) collapsing, 10% (n=

SUBMITTER: D'Agati VD 

PROVIDER: S-EPMC3586971 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature