Ferritins for Chemistry and for Life.

ABSTRACT: Ferritins, highly symmetrical protein nanocages, are reactors for Fe²⁺ and dioxygen or hydrogen peroxide that are found in all kingdoms of life and in many different cells of multicellular organisms. They synthesize iron concentrates required for cells to make cofactors of iron proteins (heme, FeS, mono and diiron). The caged ferritin biominerals, Fe₂O₃•H₂O are also antioxidants, acting as sinks for iron and oxidants scavenged from damaged proteins; genetic regulation of ferritin biosynthesis is sensitive to both iron and oxidants. Here, the emphasis here is ferritin oxidoreductase chemistry, ferritin ion channels for Fe ²⁺ transit into and out of the protein cage and Fe ³⁺ O mineral nucleation, and uses of ferritin cages in

SUBMITTER: Theil EC 

PROVIDER: S-EPMC3587046 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature