Correlation between hyaluronic acid,hyaluronic Acid synthase and human renal clear cell carcinoma.

ABSTRACT:

Objective

To study the correlation between hyaluronic acid (HA), hyaluronic acid synthase (HAS) and human renal clear cell carcinoma (RCCC).

Methods

The expression of three HAS isoforms' gene and HA in 93 RCCC tissues, 27 nephridial tissues by the side of RCCC from two hospitals were measured with Real-Time RT-PCR、Western Blot and immunohistochemical methods and analyzed.

Results

All RCCC and adjacent normal tissues expressed three HASs' mRNA & protein; at the mRNA level, both RCCC and adjacent normal tissues, expressed more HAS3 than HAS1 or HAS2, their differences were statistically significant (all P values <0.05); but, at the protein level, all HAS isoforms presented the equivalent expression. Compared with the adjacent non-neoplastic kidney tissues, the expressio

SUBMITTER: Cai JL 

PROVIDER: S-EPMC3587526 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature