Statin therapy and mortality in HIV-infected individuals; a Danish nationwide population-based cohort study.

ABSTRACT:

Background

Recent studies have suggested that statins possess diverse immune modulatory and anti-inflammatory properties. As statins might attenuate inflammation, statin therapy has been hypothesized to reduce mortality in HIV-infected individuals. We therefore used a Danish nationwide cohort of HIV-infected individuals to estimate the impact of statin use on mortality before and after a diagnosis of cardiovascular disease, chronic kidney disease or diabetes.

Methods

We identified all Danish HIV-infected individuals (1,738) who initiated HAART after 1 January 1998, and achieved virological suppression within 180 days. Date of first redemption of a prescription of statin was obtained from the Danish National Prescription Registry. We used Poisson regression analysis to assess

SUBMITTER: Rasmussen LD 

PROVIDER: S-EPMC3587599 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature