Comparing apples and oranges: fold-change detection of multiple simultaneous inputs.

ABSTRACT: Sensory systems often detect multiple types of inputs. For example, a receptor in a cell-signaling system often binds multiple kinds of ligands, and sensory neurons can respond to different types of stimuli. How do sensory systems compare these different kinds of signals? Here, we consider this question in a class of sensory systems - including bacterial chemotaxis- which have a property known as fold-change detection: their output dynamics, including amplitude and response time, depends only on the relative changes in signal, rather than absolute changes, over a range of several decades of signal. We analyze how fold-change detection systems respond to multiple signals, using mathematical models. Suppose that a step of fold F1 is made in input 1, together with a step of F2 in input 2. Wha

SUBMITTER: Hart Y 

PROVIDER: S-EPMC3587607 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature