The association between histamine 2 receptor antagonist use and Clostridium difficile infection: a systematic review and meta-analysis.

ABSTRACT:

Background

Clostridium difficile infection (CDI) is a major health problem. Epidemiological evidence suggests that there is an association between acid suppression therapy and development of CDI.

Purpose

We sought to systematically review the literature that examined the association between histamine 2 receptor antagonists (H2RAs) and CDI.

Data source

We searched Medline, Current Contents, Embase, ISI Web of Science and Elsevier Scopus from 1990 to 2012 for all analytical studies that examined the association between H2RAs and CDI.

Study selection

Two authors independently reviewed the studies for eligibility.

Data extraction

Data about studies characteristics, adjusted effect estimates and quality were extracted.

Data synthesis

Thirty-five observ

SUBMITTER: Tleyjeh IM 

PROVIDER: S-EPMC3587620 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature