Early loss of pericytes and perivascular stromal cell-induced scar formation after stroke.

ABSTRACT: Despite its limited regenerative capacity, the central nervous system (CNS) shares more repair mechanisms with peripheral tissues than previously recognized. Scar formation is a ubiquitous healing mechanism aimed at patching tissue defects via the generation of fibrous extracellular matrix (ECM). This process, orchestrated by stromal cells, can unfavorably affect the capacity of tissues to restore function. Vascular mural cells have been found to contribute to scarring after spinal cord injury. In the case of stroke, little is known about the responses of pericytes (PCs) and stromal cells. Here, we show that capillary PCs are rapidly lost after cerebral ischemia in both experimental and human stroke. Coincident with this loss is a massive proliferation of resident platelet-derived growth f

SUBMITTER: Fernandez-Klett F 

PROVIDER: S-EPMC3587816 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature