In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI.

ABSTRACT: Cerebrovascular disease has an important role in cognitive decline and dementia. In this context, cerebral microinfarcts are attracting increasing attention, but these lesions could thus far not be detected in vivo. The aim of this study was to try to identify possible cortical microinfarcts on high-resolution 7T in vivo magnetic resonance imaging (MRI) and to perform a histopathologic validation study on similar appearing lesions on 7T ex vivo MRI of postmortem brain tissue. The study population consisted of 22 elderly subjects, who underwent 7T MRI. The fluid attenuated inversion recovery, T(2), and T(1) weighted scans of these subjects were examined for possible cortical microinfarcts. In the ex vivo MRI study, 15 formalin-fixed coronal brain slices of 6 subjects with Alzheimer and vasc

SUBMITTER: van Veluw SJ 

PROVIDER: S-EPMC3587820 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature