Power comparison of admixture mapping and direct association analysis in genome-wide association studies.

ABSTRACT: When dense markers are available, one can interrogate almost every common variant across the genome via imputation and single nucleotide polymorphism (SNP) test, which has become a routine in current genome-wide association studies (GWASs). As a complement, admixture mapping exploits the long-range linkage disequilibrium (LD) generated by admixture between genetically distinct ancestral populations. It is then questionable whether admixture mapping analysis is still necessary in detecting the disease associated variants in admixed populations. We argue that admixture mapping is able to reduce the burden of massive comparisons in GWASs; it therefore can be a powerful tool to locate the disease variants with substantial allele frequency differences between ancestral populations. In this repo

SUBMITTER: Qin H 

PROVIDER: S-EPMC3589174 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature