Fat mass and obesity gene and cognitive decline: the Atherosclerosis Risk in Communities Study.

ABSTRACT:

Objective

To determine whether 4 genetic variants in the fat mass and obesity associated gene (FTO) identified in genome-wide association studies of diabetes and obesity are associated with cognitive change in midlife in the Atherosclerosis Risk in Communities (ARIC) Study.

Methods

ARIC is a prospective cohort study of the development of atherosclerosis in 15,792 individuals aged 45 to 64 years at baseline from 1986 to 1989. FTO is highly expressed in human fetal and adult brain, and a single nucleotide polymorphism in FTO has previously been associated with reduced brain volume in cognitively normal subjects. Since a relationship between brain atrophy and diminished cognitive function has been demonstrated in ARIC participants, general linear models were used to evaluate th

SUBMITTER: Bressler J 

PROVIDER: S-EPMC3589198 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature