Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning.

ABSTRACT:

Objective

To determine the effect of clinical and radiologic disease activity on the rate of thinning of the ganglion cell/inner plexiform (GCIP) layer and the retinal nerve fiber layer in patients with multiple sclerosis (MS) using optical coherence tomography (OCT).

Methods

One hundred sixty-four patients with MS and 59 healthy controls underwent spectral-domain OCT scans every 6 months for a mean follow-up period of 21.1 months. Baseline and annual contrast-enhanced brain MRIs were performed. Patients who developed optic neuritis during follow-up were excluded from analysis.

Results

Patients with the following features of disease activity during follow-up had faster rates of annualized GCIP thinning: relapses (42% faster, p = 0.007), new gadolinium-enhancing lesion

SUBMITTER: Ratchford JN 

PROVIDER: S-EPMC3589201 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature