Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency.

ABSTRACT:

Objective

To characterize the magnitude and course of alterations in total and free lamotrigine (LTG) clearance (Cl) during pregnancy and the postpartum period, to assess the impact of therapeutic drug monitoring (TDM) on seizure frequency, to determine the ratio to individual target LTG concentration that is associated with increased seizure risk, and to evaluate maternal postpartum toxicity.

Methods

A cohort of women were enrolled before conception or during pregnancy in this prospective, observational study. Visits occurred every 1 to 3 months with review of seizure and medication diaries, examination, and blood sampling. Total and free LTG Cls were calculated. Individualized target concentrations were used for TDM. The ratio to target concentration (RTC) was compared bet

SUBMITTER: Pennell PB 

PROVIDER: S-EPMC3589527 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature