Antibiotic-Releasing Silk Biomaterials for Infection Prevention and Treatment.

ABSTRACT: Effective treatment of infections in avascular and necrotic tissues can be challenging due to limited penetration into the target tissue and systemic toxicities. Controlled release polymer implants have the potential to achieve the high local concentrations needed while also minimizing systemic exposure. Silk biomaterials possess unique characteristics for antibiotic delivery including biocompatibility, tunable biodegradation, stabilizing effects, water-based processing and diverse material formats. We report on functional release of antibiotics spanning a range of chemical properties from different material formats of silk (films, microspheres, hydrogels, coatings). The release of penicillin and ampicillin from bulk-loaded silk films, drug-loaded silk microspheres suspended in silk hydrog

SUBMITTER: Pritchard EM 

PROVIDER: S-EPMC3589549 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature