Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease.

ABSTRACT:

Purpose

EGFR-mutant lung cancer was first described as a new clinical entity in 2004. Here, we present an update on new controversies and conclusions regarding the disease.

Methods

This article reviews the clinical implications of EGFR mutations in lung cancer with a focus on epidermal growth factor receptor tyrosine kinase inhibitor resistance.

Results

The discovery of EGFR mutations has altered the ways in which we consider and treat non-small-cell lung cancer (NSCLC). Patients whose metastatic tumors harbor EGFR mutations are expected to live longer than 2 years, more than double the previous survival rates for lung cancer.

Conclusion

The information presented in this review can guide practitioners and help them inform their patients about EGFR mutations and

SUBMITTER: Ohashi K 

PROVIDER: S-EPMC3589701 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature