Ontology highlight
ABSTRACT:
SUBMITTER: Ranzani M
PROVIDER: S-EPMC3589714 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Nature methods 20130113 2
Transposons and γ-retroviruses have been efficiently used as insertional mutagens in different tissues to identify molecular culprits of cancer. However, these systems are characterized by recurring integrations that accumulate in tumor cells and that hamper the identification of early cancer-driving events among bystander and progression-related events. We developed an insertional mutagenesis platform based on lentiviral vectors (LVVs) by which we could efficiently induce hepatocellular carcino ...[more]