Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma.

ABSTRACT:

Purpose

It has been hypothesized that vitamin D mediates the inverse relationship between sun exposure and non-Hodgkin lymphoma (NHL) risk reported in several recent studies. We evaluated the association of self-reported sun exposure at ages <13, 13-21, 22-40, and 41+ years and 19 single nucleotide polymorphisms (SNPs) from 4 candidate genes relevant to vitamin D metabolism (RXR, VDR , CYP24A1, CYP27B1) with NHL risk.

Methods

This analysis included 1,009 newly diagnosed NHL cases and 1,233 frequency-matched controls from an ongoing clinic-based study. Odds ratios (OR), 95 % confidence intervals (CI), and tests for trend were estimated using unconditional logistic regression.

Results

There was a significant decrease in NHL risk with increased sun exposure at ages 13-21

SUBMITTER: Kelly JL 

PROVIDER: S-EPMC3589750 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature