Consequences of stopping and restarting leptin in an adolescent with lipodystrophy.

ABSTRACT:

Background/aims

Lipodystrophy encompasses a group of rare disorders characterized by deficiency of adipose tissue resulting in hypoleptinemia, and metabolic abnormalities including insulin resistance, diabetes, dyslipidemia, and nonalcoholic steatohepatitis. Leptin replacement effectively ameliorates these metabolic derangements. We report effects of leptin discontinuation and resumption in a child with acquired generalized lipodystrophy.

Methods

Intermittent treatment with leptin with follow-up over 5 years.

Results

Pretreatment metabolic abnormalities included insulin resistance, hypertriglyceridemia and steatohepatitis. Leptin was started at the age of 10 years. After 2 years, the family requested discontinuation of leptin due to lack of visible physical changes. N

SUBMITTER: Kamran F 

PROVIDER: S-EPMC3590018 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature