Large-vessel correlates of cerebral small-vessel disease.

ABSTRACT:

Objective

Our aim was to investigate the relationship of carotid structure and function with MRI markers of cerebral ischemic small-vessel disease.

Methods

The study comprised 1,800 participants (aged 72.5 ± 4.1 years, 59.4% women) from the 3C-Dijon Study, a population-based, prospective cohort study, who had undergone quantitative brain MRI and carotid ultrasound. We used multivariable logistic and linear regression adjusted for age, sex, and vascular risk factors.

Results

Presence of carotid plaque and increasing carotid lumen diameter (but not common carotid artery intima-media thickness) were associated with higher prevalence of lacunar infarcts: odds ratio (OR) = 1.60 (95% confidence interval [CI]: 1.09-2.35), p = 0.02 and OR = 1.24 (95% CI: 1.02-1.50), p = 0.03

SUBMITTER: Brisset M 

PROVIDER: S-EPMC3590057 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature