The THRombolysis and STatins (THRaST) study.

ABSTRACT:

Objective

To assess the impact on stroke outcome of statin use in the acute phase after IV thrombolysis.

Methods

Multicenter study on prospectively collected data of 2,072 stroke patients treated with IV thrombolysis. Outcome measures of efficacy were neurologic improvement (NIH Stroke Scale [NIHSS] ≤ 4 points from baseline or NIHSS = 0) and major neurologic improvement (NIHSS ≤ 8 points from baseline or NIHSS = 0) at 7 days and favorable (modified Rankin Scale [mRS] ≤ 2) and excellent functional outcome (mRS ≤ 1) at 3 months. Outcome measures of safety were 7-day neurologic deterioration (NIHSS ≥ 4 points from baseline or death), symptomatic intracerebral hemorrhage type 2 with NIHSS ≥ 4 points from baseline or death within 36 hours, and 3-month death.

Results

Adjust

SUBMITTER: Cappellari M 

PROVIDER: S-EPMC3590058 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature