Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration.

ABSTRACT:

Objective

To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD).

Methods

Using 0-, 6-, 12-, 18-, 24-, and 36-month MRI scans of controls and subjects with MCI and AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, we calculated volume change of whole brain, hippocampus, and ventricles between all pairs of scans using the boundary shift integral.

Results

We found no evidence of acceleration in whole-brain atrophy rates in any group. There was evidence that hippocampal atrophy rates in MCI subjects accelerate by 0.22%/year2 on average (p = 0.037). There was evidence of acceleration in rates of ventricu

SUBMITTER: Leung KK 

PROVIDER: S-EPMC3590059 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature