Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses.

ABSTRACT:

Background

Iron and its homeostasis are intimately related to inflammatory responses, but the underlying molecular mechanisms are poorly understood. We investigated the role of Steap3 in regulating iron homeostasis in macrophages, and the effects of Steap3 depletion on host inflammatory responses.

Design and methods

We analyzed bone marrow-derived macrophages and primary cultured hepatocytes from Steap3(-/-) mouse models to investigate the roles of Steap3 in coordinately regulating iron homeostasis and inflammatory responses. First, we examined iron distribution and iron status in cells deficient in Steap3, as well as the requirement for the Steap3 gene during inflammatory responses. Secondly, we analyzed the regulation of Steap3 expression by inflammatory stimuli and thus,

SUBMITTER: Zhang F 

PROVIDER: S-EPMC3590089 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature