Differential expression of miR-145 in children with Kawasaki disease.

ABSTRACT:

Background

Kawasaki disease is an acute, self-limited vasculitis of childhood that can result in structural damage to the coronary arteries. Previous studies have implicated the TGF-β pathway in disease pathogenesis and generation of myofibroblasts in the arterial wall. microRNAs are small non-coding RNAs that modulate gene expression at the post-transcriptional level and can be transported between cells in extracellular vesicles. To understand the role that microRNAs play in modifying gene expression in Kawasaki disease, we studied microRNAs from whole blood during the acute and convalescent stages of the illness.

Methodology/principal findings

RNA isolated from the matched whole blood of 12 patients with acute and convalescent Kawasaki disease were analyzed by sequencing o

SUBMITTER: Shimizu C 

PROVIDER: S-EPMC3590129 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature