Protein arginine methyltransferase 1 interacts with and activates p38α to facilitate erythroid differentiation.

ABSTRACT: Protein arginine methylation is emerging as a pivotal posttranslational modification involved in regulating various cellular processes; however, its role in erythropoiesis is still elusive. Erythropoiesis generates circulating red blood cells which are vital for body activity. Deficiency in erythroid differentiation causes anemia which compromises the quality of life. Despite extensive studies, the molecular events regulating erythropoiesis are not fully understood. This study showed that the increase in protein arginine methyltransferase 1 (PRMT1) levels, via transfection or protein transduction, significantly promoted erythroid differentiation in the bipotent human K562 cell line as well as in human primary hematopoietic progenitor CD34(+) cells. PRMT1 expression enhanced the production

SUBMITTER: Hua WK 

PROVIDER: S-EPMC3590204 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature