The CshA DEAD-box RNA helicase is important for quorum sensing control in Staphylococcus aureus.

ABSTRACT: DEAD-box RNA helicases are present in almost all living organisms and participate in various processes of RNA metabolism. Bacterial proteins of this large family were shown to be required for translation initiation, ribosome biogenesis and RNA decay. The latter is primordial for rapid adaptation to changing environmental conditions. In particular, the RhlB RNA helicase from E. coli was shown to assist the bacterial degradosome machinery. Recently, the CshA DEAD-box proteins from Bacillus subtilis and Staphylococcus aureus were shown to interact with proteins that are believed to form the degradosome. S. aureus can cause life-threatening disease, with particular concern focusing on biofilm formation on catheters and prosthetic devices, since in this form the bacteria are almost impossible t

SUBMITTER: Oun S 

PROVIDER: S-EPMC3590232 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature