Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity.

ABSTRACT: Autophagy is a cellular self-digestion process that mediates protein quality control and serves to protect against neurodegenerative disorders, infections, inflammatory diseases and cancer. Current evidence suggests that autophagy can selectively remove damaged organelles such as the mitochondria. Mitochondria-induced oxidative stress has been shown to play a major role in a wide range of pathologies in several organs, including the heart. Few studies have investigated whether enhanced autophagy can offer protection against mitochondrially-generated oxidative stress. We induced mitochondrial stress in cardiomyocytes using antimycin A (AMA), which increased mitochondrial superoxide generation, decreased mitochondrial membrane potential and depressed cellular respiration. In addition, AMA au

SUBMITTER: Dutta D 

PROVIDER: S-EPMC3590254 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature