The immediate early gene product EGR1 and polycomb group proteins interact in epigenetic programming during chondrogenesis.

ABSTRACT: Initiation of and progression through chondrogenesis is driven by changes in the cellular microenvironment. At the onset of chondrogenesis, resting mesenchymal stem cells are mobilized in vivo and a complex, step-wise chondrogenic differentiation program is initiated. Differentiation requires coordinated transcriptomic reprogramming and increased progenitor proliferation; both processes require chromatin remodeling. The nature of early molecular responses that relay differentiation signals to chromatin is poorly understood. We here show that immediate early genes are rapidly and transiently induced in response to differentiation stimuli in vitro. Functional ablation of the immediate early factor EGR1 severely deregulates expression of key chondrogenic control genes at the onset of differen

SUBMITTER: Spaapen F 

PROVIDER: S-EPMC3590300 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature