DNA copy number variations characterize benign and malignant thyroid tumors.

ABSTRACT:

Context

Fine-needle aspiration (FNA) is the best diagnostic tool for preoperative evaluation of thyroid nodules but is often inconclusive as a guide for surgical management.

Objective

Our hypothesis was that thyroid tumor subtypes may show characteristic DNA copy number variation (CNV) patterns, which may further improve the preoperative classification.

Design

Our study cohorts included benign follicular adenomas (FAs), classic papillary thyroid carcinomas (PTCs), and follicular variant PTCs (FVPTCs), the three subtypes most commonly associated with inconclusive preoperative cytopathology.

Setting

Tissue and FNA samples were obtained at an academic tertiary referral center.

Patients

Cases were identified that underwent partial or complete thyroidectomy f

SUBMITTER: Liu Y 

PROVIDER: S-EPMC3590464 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature