Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma.

ABSTRACT:

Context

Oncogenic osteomalacia, a paraneoplastic syndrome associated with hypophosphatemia due to increased urinary phosphate excretion, is caused by excessive synthesis and secretion of fibroblast growth factor 23 (FGF23), a phosphaturic hormone that is normally produced by osteocytes. Most cases of oncogenic osteomalacia have been associated with benign tumors of bone or soft tissue; however, whether malignant neoplasms can also produce and secrete FGF23 is currently unknown.

Objective

The aim was to determine whether a malignant neoplasm could cause oncogenic osteomalacia through excessive production and secretion of FGF23.

Setting

We describe an 80-year-old woman with stage IV colon adenocarcinoma who presented with severe hypophosphatemia (0.4 mg/dL; reference, 2

SUBMITTER: Leaf DE 

PROVIDER: S-EPMC3590480 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature