Comparing the performance of six human papillomavirus tests in a screening population.

ABSTRACT:

Background

Several new assays have been developed for high-risk HPV testing of cervical samples; we compare six HPV tests in a screening population.

Methods

Residual material from liquid-based PreservCyt samples was assayed. Four tests (Hybrid Capture 2, Cobas, Abbott and Becton-Dickinson (BD)) measured HPV DNA while two used RNA (APTIMA and NorChip).

Results

Positivity rates ranged from 13.4 to 16.3% for the DNA-based tests with a significantly lower positivity rate for the Abbott assay. The Gen-Probe APTIMA assay was positive in 10.3% of women, which was significantly lower than all the DNA tests; the NorChip PreTect HPV-Proofer test was much lower at 5.2%. 40 CIN2+ cases were identified, of which 19 were CIN3+. All CIN3+ cases were HPV positive by all tests except

SUBMITTER: Cuzick J 

PROVIDER: S-EPMC3590662 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature