Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer.

ABSTRACT:

Background

The host immune reaction is represented by immune/inflammatory cell infiltrates. Here we systematically analysed tumour-infiltrating immune/inflammatory cells in pancreatic ductal carcinoma (PDC) and evaluated their clinicopathological impact.

Methods

Using immunohistochemistry, we examined tumour-infiltrating CD68(+) pan-macrophages, HLA-DR(+)CD68(+) M1 macrophages (M1), CD163(+) or CD204(+) M2 macrophages (M2), CD66b(+) neutrophils (Neu), CD4(+) T cells (CD4(+)T), CD8(+) T cells (CD8(+)T), and FOXP3(+)CD4(+) regulatory T cells (Treg) in 212 cases of PDC, and conducted correlation and survival analyses using the Kaplan-Meier method and Cox proportional hazards model.

Results

Higher levels of tumour-infiltrating pan-macrophages, M2, Neu, or the ratio of Tre

SUBMITTER: Ino Y 

PROVIDER: S-EPMC3590668 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature