Paper spray ionization of polar analytes using non-polar solvents.

ABSTRACT: Non-polar solvents like hexane allow ionization of insoluble drugs, peptides, nucleotides and phospholipids as solids from paper. Ambient ionization is achieved simply by application of a high voltage to the wet paper. Transport and ionization mechanisms are discussed, including the possibility of field desorption from dendritic structures formed on the paper.

SUBMITTER: Li A 

PROVIDER: S-EPMC3591489 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature