Physical activity, change in biomarkers of myocardial stress and injury, and subsequent heart failure risk in older adults.

ABSTRACT:

Objectives

The aim of this study was to evaluate the association between physical activity and changes in levels of highly sensitive troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), and the subsequent risk of the development of heart failure (HF) in community-dwelling older adults.

Background

Higher baseline levels of cTnT and NT-proBNP and increases over time correlate with the risk of HF in older adults. Factors modifying these levels have not been identified.

Methods

NT-proBNP and cTnT were measured at baseline and 2 to 3 years later in adults 65 years of age and older free of HF participating in the Cardiovascular Health Study. Self-reported physical activity and walking pace were combined into a composite score. An increase was prespec

SUBMITTER: deFilippi CR 

PROVIDER: S-EPMC3591516 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature