Protective effects of Lactobacillus plantarum CCFM8610 against acute cadmium toxicity in mice.

ABSTRACT: This study evaluated the protective effects of Lactobacillus plantarum CCFM8610, a selected probiotic with good cadmium binding capacity, against acute cadmium toxicity in mice. Ninety mice were divided into prevention and therapy groups. In the prevention groups, CCFM8610 was administered at 10(9) CFU once daily for 7 days, followed by a single oral dose of cadmium chloride at 1.8 mg cadmium for each mouse. In the therapy groups, the same dose of CCFM8610 was administered for 2 days after an identical single dose of cadmium exposure. Mice that received neither cadmium nor culture or that received cadmium alone served as negative and positive controls, respectively. The effects of both living and dead CCFM8610 on cadmium ion concentrations in feces, liver, and kidney were determined. Moreo

SUBMITTER: Zhai Q 

PROVIDER: S-EPMC3591948 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature