Use of statins and risk of glioma: a nationwide case-control study in Denmark.

ABSTRACT:

Background

Laboratory studies and a single case-control study have suggested a protective effect of statins on the risk of glioma. We wished to investigate the influence of statin use on the risk of glioma in a population-based setting.

Methods

We conducted a nationwide case-control study in Denmark based on population-based medical registries. We identified all patients aged 20 to 85 years with a first diagnosis of histologically verified glioma during 2000-2009. These cases were matched on birth year and sex with population controls. Prior use of statins since 1995 was classified into short-term use (<5 years) and long-term use (5+ years). We used conditional logistic regression to compute odds ratios (ORs), with 95% confidence intervals (CIs), for glioma associated with s

SUBMITTER: Gaist D 

PROVIDER: S-EPMC3593536 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature