An orchestrated program regulating secretory pathway genes and cargos by the transmembrane transcription factor CREB-H.

ABSTRACT: CREB3 proteins comprise a set of ER-localized bZip transcription factors defined by the presence of a transmembrane domain. They are regulated by inter-compartmental transport, Golgi cleavage and nuclear transport where they promote appropriate transcriptional responses. Although CREB3 proteins play key roles in differentiation, inflammation and metabolism, a general framework relating their defining features to these diverse activities is lacking. We identify unique features of CREB3 organization including the ATB domain, which we show it is essential for transcriptional activity. This domain is absent in all other human bZip factors, but conserved in Drosophila CREBA, which controls secretory pathway genes (SPGs). Furthermore, each of the five human CREB3 factors was capable of activatin

SUBMITTER: Barbosa S 

PROVIDER: S-EPMC3593995 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature