Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target.

ABSTRACT: Glioblastoma is the most common form of primary adult brain tumors. A majority of glioblastomas grow invasively into distant brain tissue, leading to tumor recurrence, which is ultimately incurable. It is, therefore, essential to discover master regulators that control glioblastoma invasiveness and target them therapeutically. We show here that the transcriptional regulator Id-1 plays a critical role in modulating the invasiveness of glioblastoma cell lines and primary glioblastoma cells. Id-1 expression levels positively correlate with glioma cell invasiveness in culture and with histopathologic grades in patient biopsies. Id-1 knockdown dramatically reduces glioblastoma cell invasion that is accompanied by profound morphologic changes and robust reduction in expression levels of "mesench

SUBMITTER: Soroceanu L 

PROVIDER: S-EPMC3594064 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature