The properties of genome conformation and spatial gene interaction and regulation networks of normal and malignant human cell types.

ABSTRACT: The spatial conformation of a genome plays an important role in the long-range regulation of genome-wide gene expression and methylation, but has not been extensively studied due to lack of genome conformation data. The recently developed chromosome conformation capturing techniques such as the Hi-C method empowered by next generation sequencing can generate unbiased, large-scale, high-resolution chromosomal interaction (contact) data, providing an unprecedented opportunity to investigate the spatial structure of a genome and its applications in gene regulation, genomics, epigenetics, and cell biology. In this work, we conducted a comprehensive, large-scale computational analysis of this new stream of genome conformation data generated for three different human leukemia cells or cell lines

SUBMITTER: Wang Z 

PROVIDER: S-EPMC3594155 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature