Waist circumference independently associates with the risk of insulin resistance and type 2 diabetes in mexican american families.

ABSTRACT:

Objective

In spite of the growing recognition of the specific association of waist circumference (WC) with type 2 diabetes (T2D) and insulin resistance (IR), current guidelines still use body mass index (BMI) as a tool of choice. Our objective was to determine whether WC is a better T2D predictor than BMI in family-based settings.

Research design and methods

Using prospectively collected data on 808 individuals from 42 extended Mexican American families representing 7617.92 person-years follow-up, we examined the performance of WC and BMI as predictors of cumulative and incident risk of T2D. We used robust statistical methods that accounted for the kinships and included polygenic models, discrete trait modeling, Akaike information criterion, odds ratio (OR), relative risk (R

SUBMITTER: Mamtani M 

PROVIDER: S-EPMC3594157 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature